Cetaphil Deep Hydration Activation Serum — 1 fl oz Fragrance-Free, 48-Hour Hyaluronic Acid

Made for sensitive and dehydrated skin, this 1 fl oz serum blends a HydroSensitiv complex with hyaluronic acid, vitamin B5, vitamin E and sunflower seed oil to boost skin hydration and comfort. It absorbs quickly, layers easily under creams or makeup, and is clinically tested on sensitive skin to avoid irritation and pore blockage. The formula aims to improve skin texture and reduce feelings of tightness caused by dryness without adding fragrance.

How does this serum provide 48-hour hydration?

The serum combines humectants and plant oils that attract and help retain moisture in the skin. Hyaluronic acid draws water into the surface layers while HydroSensitiv complex supports ongoing hydration, helping skin feel plumper and less dry between applications.

• Hyaluronic acid holds moisture at the skin surface.
• HydroSensitiv complex helps sustain dynamic hydration.
• Sunflower seed oil and vitamin E add barrier-nourishing lipids.
• Lightweight texture absorbs quickly without residue.

Can I use this serum with other products in my routine?

Yes — the formula is designed to layer well under moisturizers, sunscreens and makeup. Apply a few drops after cleansing and before a cream or lotion for an extra hydration boost, or use it alone when you prefer a lighter finish.

• Works under daily moisturizer or sunscreen.
• Compatible with most serums and treatments; patch test new mixes.
• Use both morning and night for consistent hydration support.
• Non-comedogenic, so it won’t typically clog pores when layered.

Is this safe for sensitive or reactive skin?

The product is fragrance-free and clinically tested on sensitive skin to minimize irritation risk. Its gentle blend focuses on hydration and strengthening the skin’s surface without harsh additives commonly associated with sensitivity.

• Fragrance-free to reduce irritation triggers.
• Formulated to be non-irritating and non-comedogenic.
• Includes soothing vitamin B5 to help comfort dry skin.
• Clinically tested on sensitive skin types.

How should I apply the serum for best results?

For optimal performance, apply to clean, slightly damp skin to help the hyaluronic acid draw in moisture. Use a pea-sized amount or a few drops and gently pat across face and neck, following with a moisturizer if needed to seal hydration.

• Apply to face and neck after cleansing, on damp skin if possible.
• Use morning and evening for ongoing hydration support.
• Layer under creams, sunscreens or makeup as part of regular routine.
• A small amount spreads widely — no heavy application required.

Who is this for: Cetaphil Deep Hydration 48 Hour Activation Serum is aimed at people with dry, dehydrated or sensitive skin who want long-lasting moisture without added fragrance or heavy textures. It suits those who prefer a lightweight base that layers under moisturizers and makeup, and anyone seeking a dermatologist-recommended, gentle option to help improve skin comfort and appearance between treatments.

Ingredients

Water, Glycerin, Sorbitol, Coco-Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Helianthus Annuus (Sunflower) Seed Oil, Octyldodecanol, Hexyldecanol, Hexyldecyl Laurate, Distarch Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Butyrospermum Parkii(Shea)Oil, Citric Acid, Dicaprylyl Carbonate, Disodium Cocoyl Glutamate, Globulariaalypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Panthenol (Vitamin B5), Pantolactone, Phenoxyethanol, Propylene Glycol, Sodium Benzoate, Sodium Hydroxide, Sodium Polyacrylate, Tocopherol (Vitamin E), Tocopheryl Acetate (Vitamin E Acetate), Xylitol, Xylitylglucoside