PanOxyl Adapalene 0.1% Retinoid Gel Acne Treatment — 0.5 oz 30-Day Supply, Oil- and Fragrance-Free

PanOxyl Adapalene 0.1% Leave-On Gel is a once-daily, non-prescription topical retinoid designed to help reduce acne breakouts while remaining oil-, fragrance-, and paraben-free.

This dermatologist-developed gel delivers adapalene USP 0.1%, the first topical retinoid cleared for over-the-counter use, in an easy leave-on formula suitable for acne-prone skin. Formulated without oils, fragrances, or parabens, it’s intended to integrate into an everyday nighttime routine and support skin appearance with a single nightly application. The product comes as a 0.5 oz tube, providing roughly a 30-day supply when used as directed.

How does this gel fit into my nightly skincare routine?

Apply PanOxyl Adapalene 0.1% once a day in the evening after cleansing and drying your face. Use a pea-sized amount, spread thinly over affected areas, and follow with your usual moisturizer if needed. Avoid combining with other potentially irritating actives unless advised by a dermatologist.

• Apply to clean, dry skin once nightly.
• Use a pea-sized amount for the entire face or targeted areas.
• Layer moisturizer over the gel to reduce dryness if necessary.

What improvements can I expect and when will I see them?

Results vary between users, but many people notice gradual improvement in breakouts and skin texture over several weeks of consistent use. Because adapalene is a retinoid, it works over time to help address the factors that contribute to acne rather than delivering instant clearing. Continue regular application and consult a dermatologist if you have concerns about irritation.

• Initial changes often appear within 4–12 weeks for many users.
• Consistent nightly use maximizes benefits.
• Discontinue and seek advice if significant irritation occurs.

Is this formula gentle enough for sensitive or oily skin?

PanOxyl Adapalene 0.1% is formulated to be oil-free, fragrance-free, and paraben-free, which helps reduce the risk of added irritation for oily or sensitive skin types. That said, retinoids can cause temporary dryness or redness while skin adapts; using a gentle cleanser and a non-comedogenic moisturizer can help manage those effects. If you have very sensitive skin, consider starting every other night or consulting a dermatologist first.

• Oil-free base prevents extra pore-clogging oils.
• No added fragrance or parabens to minimize irritants.
• Moisturize to control dryness during the adjustment period.

Can I use other acne products at the same time?

Combining multiple active treatments can increase irritation, so integrate other acne products cautiously. Avoid concurrent use of abrasive scrubs, chemical exfoliants, or stronger prescription retinoids without professional guidance. If you use benzoyl peroxide or salicylic acid, monitor skin response and space applications to reduce the chance of dryness or inflammation.

• Introduce new actives one at a time and watch for irritation.
• Space different treatments (e.g., morning vs. night) to minimize overlap.
• Consult a dermatologist before mixing prescription-strength products.

Who is this for: PanOxyl Adapalene 0.1% Leave-On Gel is intended for adults and teens with acne-prone skin who want an OTC retinoid option that’s fragrance-free, oil-free, and paraben-free. It suits people seeking a once-daily, dermatologist-developed treatment to incorporate into an evening routine; if you have highly reactive skin or are using certain prescription treatments, check with a healthcare professional before starting.

Ingredients

carbomer homopolymer type C, edetate disodium, phenoxyethanol, poloxamer 182, propylene glycol, purified water, sodium hydroxide