Cetaphil Healthy Renew Night Cream — Skin Tightening Wrinkle Repair 1.7 oz, Peptides & Fragrance-Free

This rich night cream from Cetaphil is formulated to hydrate deeply and support a healthier-looking skin surface by morning. The 1.7 oz jar combines a retinol alternative (purified peptides) with vitamins and botanical extracts to address visible signs of aging and uneven tone without the irritation associated with traditional retinoids. It absorbs quickly, provides long-lasting moisture, and is developed to be gentle on sensitive skin types.

How fast will I see fewer fine lines and wrinkles?

Results vary by person, but clinical testing with this formula showed visible improvement in the look of fine lines within about two weeks of consistent nightly use. Continued application supports ongoing improvement in texture and smoothness.

• Clinically observed reduction in fine lines in approximately 2 weeks
• Purified peptides target skin firmness without typical retinol irritation
• Use nightly on cleansed skin for best results

Can sensitive skin tolerate this night cream?

The formulation prioritizes gentleness: it’s fragrance-free, hypoallergenic, paraben-free and dermatologist-tested. Ingredients like niacinamide (vitamin B3) and panthenol (vitamin B5) help soothe and support the skin barrier while botanical extracts address dullness.

• Fragrance-free, hypoallergenic, and paraben-free for reduced irritation risk
• Niacinamide and panthenol hydrate and calm skin overnight
• Designed to defend against dryness, irritation, roughness, tightness and barrier weakening

What active ingredients are inside and how do they work?

The cream blends a retinol alternative—purified peptides—with supportive hydrators and botanical extracts to balance anti-aging benefits and skin comfort. Rather than stimulating the same cellular pathways as retinol, peptides help promote a smoother appearance without the common sensitizing effects.

• Purified peptides: gentle alternative to retinol for visible firming and line reduction
• Niacinamide (B3): helps even tone and strengthen the barrier
• Panthenol (B5): attracts and locks in moisture for lasting hydration up to 48 hours
• Rice lees and edelweiss extracts: target visible dullness and uneven skin tone

How should I use it in my nightly routine?

Apply after cleansing and any lightweight serums, smoothing a thin layer over face and neck each night. Because it’s formulated for sensitive skin and doesn’t increase sun sensitivity like some retinoids, it integrates easily into most evening regimens.

• Use nightly on clean, dry skin—follow with eye treatments if desired
• A little goes a long way—massage gently until absorbed
• Complement with daytime SPF to protect results

Who is this for: Cetaphil Healthy Renew Night Cream is suited for people seeking a calming, effective anti-aging night moisturizer—especially those with sensitive or reactive skin who want peptide-powered improvement without retinol’s typical irritation. It fits routines that prioritize hydration, barrier support and gradual visible smoothing while remaining fragrance-free and dermatologist-recommended.

Ingredients

Water, Glycerin, Propanediol, Panthenol, 1,2-Hexandiol, Niacinamide, C13-15 Alkane, Butyrospermum Parkii (Shea) Butter, Coco Nucifera (Coconut) Oil, Sodium Polyacryloyldimethyl Taurate, Hydrogenated Polydecene, Silica, Tocopheryl Acetate, Vinyl Dimethicone, C14-22 Alcohols, Leontopodium Alpinum Extract, Polyglyceryl-2 Stearate, Polyacrylate-13, C12-20 Alkyl Glucoside, Oryza Sativa (Rice) Lees Extract, Glyceryl Stearate, Stearyl Alcohol, Polyisobutene, Hydrolyzed Soy Flour, Adenosine, Dimethicone/Vinyl Dimehicone Crosspolymer, Butylene Glycol, Trisodium Ethylenediamine Disuccinate, Acacia Senegal Gum, Citric Acid, Agar, Caprylyl Glycol, Polysorbate20, Sodium Benzoate, Sorbitan Isostearatec, Potassium Sorbate, Sodium Hyaluronate, Xanthan Gum, Ethylhexylglycerin, Buddleja Davidii Extract, Thymus Vulgaris (Thyme) Extract